Attenuated live vaccine for the active immunization of poultry against Newcastle Disease.
Pestipharm B1 is a lyophilized vaccine consisting of a live modified strain of Newcastle Disease virus propa- gated on SPF chicken embryo. One dose contains:
Newcastle Disease virus Hitchner B1 strain ………………………………….. min. 106.0 EID50.
**EID50 infection dose for 50% of chicken´s embryos.
For active immunisation of chickens against Newcastle disease, to prevent infection. The vaccine is suitable for use from the first day of life.
For administration in drinking water, intraconjuctival/ intranasal administration or by spray. Vaccine can be used from the first day of life.
Reconstitute the freeze-dried product in required volume of drinking water and use within 2 hours after reconstitution.
Individual (intraconjuctival / intranasal) administration
The volume of vaccine for vaccination of one animal is 0,1 ml ; i.e. for vaccination of 100 chickens one vial with the content of 100 vaccine doses is dissolved in 10 ml of drinking water.
Close one nasal hole by a finger and administer the vaccine into the second nasal hole at intranasal administration.
Administer the vaccine into the intraconjuctival sac at intracojuctival route.
Monitor the acceptance of full vaccination dose by every subject during administration.
Mass application in drinking water
Reconstitute the lyophilised vaccine in cold fresh drinking water free of any essences of disinfects agents, cleaners, and with- out chlorides and ions of metals immediately before use. Add defeat milk-powder in the volume of 0,4% (4 grams per one litter of drinking water) with a purpose to protect the vaccine virus. Dissolve the vaccine in such volume of drinking water, which is consumed by vaccinated poultry within 2 hours i.e. corresponding to approximately 1/7 of daily need volume of drinking water. Approximate volume can be dedicated from ratio: one litter of drinking water is needed to vaccinate to 1000 chickens at the age of one day; seven litters of drinking water is needed to vaccinate 1000 chickens at the age of seven days; 10 litters of drinking water is needed to vaccinate 1000 chickens at the age of ten days; 28 litters of drinking water is needed to vaccinate 1000 chickens at the age of 28 days … etc. The volume of drinking water for vaccination of 1000 animals older than of 40 days is minimum 40 litters.
It is recommended to take off the feed water for approximately two hours before the start of vaccination.
Serve the adequate amount of drinking water with the vaccine into a drinking system and protect it against the radiant heat.
Mass application by aerosol
Reconstitute the vaccine in drinking water free of any essences of disinfects agents, cleaners, chlorides and ions of metals.
Dissolve the vaccine in 200 ml of water when vaccinate 1000 chickens at the age of 1-28 days. 400 ml of water is needed for vaccination of 1000 animals older than 28 days.
Administered the vaccine by sprayer creating small sprinkles (robust spray) of size 30 – 60 μm during primo vaccination. Use the sprayer creating soft spray with sprinkles of size 20 – 30 μm at revaccination.
Newcastle virus may cause a mild inflammation of the eye in humans which lasts for two or three days. Care should be taken in handling the virus to avoid contact with the eyes.
Satisfactory protection can be achieved only in well-developed, healthy birds.
All susceptible birds on the same premises should be vaccinated at the same time Mix only the amount of vaccine to be used immediately and use promptly Use entire contents of bottle when first opened Burn all vaccine containers and unused contents Soft respiratory problems may occur after vaccination, they disappear spontaneously within 7 – 10 days after vaccination.
Keep out of the reach and sight of children.
Store and transport refrigerated (2 °C – 8 °C), in the dark and dry place.
PRESENTATIONS: 500 doses, 1000 doses.
FOR VETERINARY USE ONLY
MANUFACTURED: Slovak Republic